La Vitamina D en el Foco de la Enfermería: Un Análisis Sistemático de su Relación con el COVID-19

Gabriela del Cisne Valarezo Chicaiza, Silvia Pineda Hoyos, Óscar Andrés Mera Yunga, Viviana Graciela Coellar Cando

Resumen


Problema: Este estudio aborda la importante cuestión de si los niveles de vitamina D tienen un impacto significativo en la infección y mortalidad por COVID-19, especialmente desde una perspectiva de enfermería. Metodología: Se realizó una revisión bibliográfica sistemática, centrada en estudios clínicos y de investigación clínica publicados entre 2021 y 2023 en revistas de enfermería. Se utilizaron dos bases de datos: Scopus y PubMed, en castellano e inglés, aplicando criterios de inclusión como "ensayo clínico" y "investigación clínica" y exclusión para seleccionar artículos relevantes. Resultados: Se identificaron inicialmente 182 artículos, de los cuales se retuvieron 111 tras aplicar criterios de inclusión. Estos estudios se categorizaron en cuatro grupos: un 24% de los estudios no encontraron asociación significativa, un 19% relacionó el COVID-19 con bajos niveles de vitamina D, un 28% sugirió un efecto beneficioso de la vitamina D en la reducción de la infección y/o mortalidad, y un 29% afirmó que existe tal efecto beneficioso, pero enfatizó la necesidad de más investigaciones. Un análisis estadístico mediante una prueba de chi-cuadrado no reveló diferencias significativas entre estas categorías, lo que sugiere que no se puede establecer que unas conclusiones estén más marcadas que otras. Sin embargo, si es que se agrupa sugieren un efecto beneficioso y la necesidad de más investigaciones, se obtiene un significativo 57% favorable al empleo de vitamina D en el cuidado de pacientes con COVID-19. Conclusión: Este estudio destaca la complejidad de la relación entre la vitamina D y el COVID-19, subrayando la necesidad de investigaciones adicionales para obtener conclusiones más definitivas. Los hallazgos tienen implicaciones significativas para el campo de la enfermería, ya que una mejor comprensión de esta relación podría influir en la prevención y tratamiento del COVID-19.


Palabras clave


Vitamina D; COVID-19; Enfermería; Revisión sistemática; Tratamiento del COVID-19.

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Referencias


Alabdullatif, W., Almnaizel, A., Alhijji, A., Alshathri, A., Albarrag, A., & Bindayel, I. (2023). Correlation of Plasma 25(OH)D3 and Vitamin D Binding Protein Levels with COVID-19 Severity and Outcome in Hospitalized Patients. Nutrients, 15(8), Article 8. https://doi.org/10.3390/nu15081818

Aryafar, M., Gholami, F., & Bozorgmehr, R. (2023). Vitamin D status and blood group among severe COVID-19 patients. Annals of Medicine and Surgery (2012), 85(9), 4262-4267. https://doi.org/10.1097/MS9.0000000000000955

Benameur, T., Kaliyadan, F., Saidi, N., & Porro, C. (2023). A Retrospective Chart Review Evaluating Changes in 25-Hydroxyvitamin D Levels among Patients Attending the University Healthcare Centre during the COVID-19 Pandemic. Nutrients, 15(10), Article 10. https://doi.org/10.3390/nu15102345

Bennouar, S., Cherif, A. B., Kessira, A., Bennouar, D.-E., & Abdi, S. (2021). Vitamin D Deficiency and Low Serum Calcium as Predictors of Poor Prognosis in Patients with Severe COVID-19. Journal of the American College of Nutrition, 40(2), 104-110. https://doi.org/10.1080/07315724.2020.1856013

Benskin, L. L. (2020). A Basic Review of the Preliminary Evidence That COVID-19 Risk and Severity Is Increased in Vitamin D Deficiency. Frontiers in Public Health, 8, 513. https://doi.org/10.3389/fpubh.2020.00513

Beran, A., Mhanna, M., Srour, O., Ayesh, H., Stewart, J. M., Hjouj, M., Khokher, W., Mhanna, A. S., Ghazaleh, D., Khader, Y., Sayeh, W., & Assaly, R. (2022). Clinical significance of micronutrient supplements in patients with coronavirus disease 2019: A comprehensive systematic review and meta-analysis. Clinical Nutrition Espen, 48, 167-177. https://doi.org/10.1016/j.clnesp.2021.12.033

Bishop, C. W., Ashfaq, A., Melnick, J. Z., Vazquez-Escarpanter, E., Fialkow, J. A., Strugnell, S. A., Choe, J., Kalantar-Zadeh, K., Federman, N. C., Ng, D., & Adams, J. S. (2023). REsCue trial: Randomized controlled clinical trial with extended-release calcifediol in symptomatic COVID-19 outpatients. Nutrition, 107, 111899. https://doi.org/10.1016/j.nut.2022.111899

Cabrera-Tenecela, P. (2023). Nueva organización de los diseños de investigación. South American Research Journal, 3(1), 37-51. https://www.sa-rj.net/index.php/sarj/article/view/37

Cao, Z., Wu, Y., Faucon, E., & Sabatier, J.-M. (2020). SARS-CoV-2 & Covid-19: Key-Roles of the «Renin-Angiotensin» System / Vitamin D Impacting Drug and Vaccine Developments. Infectious Disorders Drug Targets, 20(3), 348-349. https://doi.org/10.2174/1871526520999200505174704

Chiodini, I., Gatti, D., Soranna, D., Merlotti, D., Mingiano, C., Fassio, A., Adami, G., Falchetti, A., Eller-Vainicher, C., Rossini, M., Persani, L., Zambon, A., & Gennari, L. (2021). Vitamin D Status and SARS-CoV-2 Infection and COVID-19 Clinical Outcomes. Frontiers in Public Health, 9. https://doi.org/10.3389/fpubh.2021.736665

di Filippo, L., Frara, S., Nannipieri, F., Cotellessa, A., Locatelli, M., Rovere Querini, P., & Giustina, A. (2023). Low Vitamin D Levels Are Associated With Long COVID Syndrome in COVID-19 Survivors. The Journal of Clinical Endocrinology and Metabolism, 108(10), e1106-e1116. https://doi.org/10.1210/clinem/dgad207

di Filippo, L., Uygur, M., Locatelli, M., Nannipieri, F., Frara, S., & Giustina, A. (2023). Low vitamin D levels predict outcomes of COVID-19 in patients with both severe and non-severe disease at hospitalization. Endocrine, 80(3), 669-683. https://doi.org/10.1007/s12020-023-03331-9

Domazet Bugarin, J., Dosenovic, S., Ilic, D., Delic, N., Saric, I., Ugrina, I., Stojanovic Stipic, S., Duplancic, B., & Saric, L. (2023). Vitamin D Supplementation and Clinical Outcomes in Severe COVID-19 Patients-Randomized Controlled Trial. Nutrients, 15(5), 1234. https://doi.org/10.3390/nu15051234

Ducharme, F. M., Tremblay, C., Golchi, S., Hosseini, B., Longo, C., White, J. H., Coviello, D., Quach, C., Ste-Marie, L.-G., & Platt, R. W. (2023). Prevention of COVID-19 with oral vitamin D supplemental therapy in essential healthcare teams (PROTECT): Protocol for a multicentre, triple-blind, randomised, placebo-controlled trial. BMJ Open, 13(5), e064058. https://doi.org/10.1136/bmjopen-2022-064058

Ebadi, M., & Montano-Loza, A. J. (2020). Perspective: Improving vitamin D status in the management of COVID-19. European Journal of Clinical Nutrition, 74(6), 856-859. https://doi.org/10.1038/s41430-020-0661-0

Elmi, Z. A. I., Sighakoli, S., Tetteh, J., & Zand, N. (2023). Case–control study of serum vitamin D concentrations in hospitalised patients with COVID-19 and hospitalised controls suffering with respiratory tract infections of differing aetiology. BMJ Nutrition, Prevention & Health, 6(1), 14-20. https://doi.org/10.1136/bmjnph-2022-000428

Grant, W. B., Lahore, H., McDonnell, S. L., Baggerly, C. A., French, C. B., Aliano, J. L., & Bhattoa, H. P. (2020). Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients, 12(4), 988. https://doi.org/10.3390/nu12040988

Hosseini, B., Dasari, H., Smyrnova, A., Bourassa, C., Leng, J., Renaud, C., & Ducharme, F. M. (2023). Concordance in COVID-19 serology, bone mineralization, and inflammatory analytes between venous and self-collected capillary blood samples exposed to various pre-analytical conditions. Annals of Clinical Biochemistry, 60(4), 259-269. https://doi.org/10.1177/00045632231159279

Hosseini, B., El Abd, A., & Ducharme, F. M. (2022). Effects of Vitamin D Supplementation on COVID-19 Related Outcomes: A Systematic Review and Meta-Analysis. Nutrients, 14(10), 2134. https://doi.org/10.3390/nu14102134

Jordan, T., Siuka, D., Rotovnik, N. K., & Pfeifer, M. (2022). COVID-19 and Vitamin D– a Systematic Review. Slovenian Journal of Public Health, 61(2), 124-132. https://doi.org/10.2478/sjph-2022-0017

Kazemi, A., Mohammadi, V., Aghababaee, S. K., Golzarand, M., Clark, C. C. T., & Babajafari, S. (2021). Association of Vitamin D Status with SARS-CoV-2 Infection or COVID-19 Severity: A Systematic Review and Meta-analysis. Advances in Nutrition, 12(5), 1636-1658. https://doi.org/10.1093/advances/nmab012

Kümmel, L. S., Krumbein, H., Fragkou, P. C., Hünerbein, B. L., Reiter, R., Papathanasiou, K. A., Thölken, C., Weiss, S. T., Renz, H., & Skevaki, C. (2022). Vitamin D supplementation for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials. Frontiers in Immunology, 13. https://www.frontiersin.org/articles/10.3389/fimmu.2022.1023903

LaRiccia, P. J., Cafaro, T., John, D., van Helmond, N., Mitrev, L. V., Bandomer, B., Brobyn, T. L., Hunter, K., Roy, S., Ng, K. Q., Goldstein, H., Tsai, A., Thwing, D., Maag, M. A., & Chung, M. K. (2023). Healthcare Costs and Healthcare Utilization Outcomes of Vitamin D3 Supplementation at 5000 IU Daily during a 10.9 Month Observation Period within a Pragmatic Randomized Clinical Trial. Nutrients, 15(20), Article 20. https://doi.org/10.3390/nu15204435

Liu, Y., Clare, S., D’Erasmo, G., Heilbronner, A., Dash, A., Krez, A., Zaworski, C., Haseltine, K., Serota, A., Miller, A., Veiga, K., Sandoval, M., T Lu, T., McMahon, D. J., Nieves, J. W., & Stein, E. M. (2023). Vitamin D and SARS-CoV-2 Infection: SERVE Study (SARS-CoV-2 Exposure and the Role of Vitamin D among Hospital Employees). The Journal of Nutrition, 153(5), 1420-1426. https://doi.org/10.1016/j.tjnut.2023.03.001

Meng, J., Li, X., Liu, W., Xiao, Y., Tang, H., Wu, Y., Xiong, Y., & Gao, S. (2023). The role of vitamin D in the prevention and treatment of SARS-CoV-2 infection: A meta-analysis of randomized controlled trials. Clinical Nutrition (Edinburgh, Scotland), 42(11), 2198-2206. https://doi.org/10.1016/j.clnu.2023.09.008

Mingiano, C., Picchioni, T., Cavati, G., Pirrotta, F., Calabrese, M., Nuti, R., Gonnelli, S., Fortini, A., Frediani, B., Gennari, L., & Merlotti, D. (2023). Vitamin D Deficiency in COVID-19 Patients and Role of Calcifediol Supplementation. Nutrients, 15(15), Article 15. https://doi.org/10.3390/nu15153392

Mishra, P., Parveen, R., Bajpai, R., & Agarwal, N. (2022). Vitamin D Deficiency and Comorbidities as Risk Factors of COVID-19 Infection: A Systematic Review and Meta-analysis. Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi, 55(4), 321-333. https://doi.org/10.3961/jpmph.21.640

Moghaddam, R. R., Khorasanchi, Z., Noor, A. R., Moghadam, M. S. F., Esfahani, A. J., Alyakobi, A. K. M., Alboresha, M. L., Sharifan, P., Bahari, A., Rezvani, R., Aghasizade, M., Heshmati, M., Darban, R. A., Ferns, G., & Mobarhan, M. G. (2023). High-dose vitamin D supplementation is related to an improvement in serum alkaline phosphatase in COVID-19 patients; a randomized double-blinded clinical trial. Journal of Health, Population, and Nutrition, 42(1), 71. https://doi.org/10.1186/s41043-023-00409-y

Moozhipurath, R. K., Kraft, L., & Skiera, B. (2020). Evidence of protective role of Ultraviolet-B (UVB) radiation in reducing COVID-19 deaths. Scientific Reports, 10(1), 17705. https://doi.org/10.1038/s41598-020-74825-z

Mosca, C., Colucci, A., Savoia, F., Calì, C., Del Bene, M., Ranucci, G., Maglione, A., Pepe, A., Morelli, A., Vajro, P., & Mandato, C. (2023). Vitamin D Levels in the Pre- and Post-COVID-19 Pandemic Periods and Related Confinement at Pediatric Age. Nutrients, 15(9), Article 9. https://doi.org/10.3390/nu15092089

Paiz, N., Alonso, P., & Portillo, A. L. (2021). Vitamin D Status: Can It Affect the Risk of Infection and the Severity of COVID-19 Symptoms? Current Tropical Medicine Reports, 8(3), 204. https://doi.org/10.1007/s40475-021-00236-3

Protas, V. V., Pogossyan, G. P., Li, K. G., Zhumina, A. G., Bisseneva, A. K., & Shaikina, D. N. (2023). Plasma 25-Hydroxyvitamin D Level and VDR Gene Single Nucleotide Polymorphism rs2228570 Influence on COVID-19 Susceptibility among the Kazakh Ethnic Group—A Pilot Study. Nutrients, 15(7), Article 7. https://doi.org/10.3390/nu15071781

Ramezani-Jolfaie, N., Eftekhar, E., Dadinasab, M., Hesarooeyeh, Z. G., Pakdaman, P., Razmpour, F., Javedan, G., Khayatian, M., Azad, M. H., Davoodian, P., Brahimi, E., Rafati, S., Nikoofal-Sahlabadi, S., & Mohammadi, M. (2023). The effect of vitamin D and magnesium supplementation on clinical symptoms and serum inflammatory and oxidative stress markers in patients with COVID-19: A structured summary of a study protocol for a randomized controlled trial. Trials, 24(1), 87. https://doi.org/10.1186/s13063-023-07107-4

Rayyan. (s. f.). Recuperado 25 de enero de 2024, de https://rayyan.ai/reviews/909257

Reino-Gelardo, S., Palop-Cervera, M., Aparisi-Valero, N., Espinosa-San Miguel, I., Lozano-Rodríguez, N., Llop-Furquet, G., Sanchis-Artero, L., Cortés-Castell, E., Rizo-Baeza, M., & Cortés-Rizo, X. (2023). Effect of an Immune-Boosting, Antioxidant and Anti-Inflammatory Food Supplement in Hospitalized COVID-19 Patients: A Prospective Randomized Pilot Study. Nutrients, 15(7), Article 7. https://doi.org/10.3390/nu15071736

Sanecka, M., Youssef, M., Abdulsalam, M., Raza, S. F., Qadeer, A., Ioana, J., Aldoresi, A., Shah, S. I., Al Lawati, A., Feely, J., Tormey, W. P., O’Neill, E., Cormican, L. J., Judge, E. P., McCartney, D. M. A., & Faul, J. L. (2023). Hospital Outcomes in Patients Hospitalized for COVID-19 Pneumonia: The Effect of SARS-CoV-2 Vaccination and Vitamin D Status. Nutrients, 15(13), Article 13. https://doi.org/10.3390/nu15132976

Shawi, H. R. S., Anvari, E., & Fateh, A. (2023). Role of FokI rs2228570 and Tru9I rs757343 Polymorphisms in the Mortality of Patients Infected with Different Variants of SARS-CoV-2. Archives of Medical Research, 54(4), 310-318. https://doi.org/10.1016/j.arcmed.2023.03.006

Simonnet, A., Chetboun, M., Poissy, J., Raverdy, V., Noulette, J., Duhamel, A., Labreuche, J., Mathieu, D., Pattou, F., Jourdain, M., & LICORN and the Lille COVID-19 and Obesity study group. (2020). High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation. Obesity (Silver Spring, Md.), 28(7), 1195-1199. https://doi.org/10.1002/oby.22831

Smaha, J., Jackuliak, P., Kužma, M., Max, F., Binkley, N., & Payer, J. (2023). Vitamin D Deficiency Prevalence in Hospitalized Patients with COVID-19 Significantly Decreased during the Pandemic in Slovakia from 2020 to 2022 Which Was Associated with Decreasing Mortality. Nutrients, 15(5), Article 5. https://doi.org/10.3390/nu15051132

Stroehlein, J. K., Wallqvist, J., Iannizzi, C., Mikolajewska, A., Metzendorf, M.-I., Benstoem, C., Meybohm, P., Becker, M., Skoetz, N., Stegemann, M., & Piechotta, V. (2021). Vitamin D supplementation for the treatment of COVID-19: A living systematic review. The Cochrane Database of Systematic Reviews, 5(5), CD015043. https://doi.org/10.1002/14651858.CD015043

The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team, null. (2020). The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19)—China, 2020. China CDC Weekly, 2(8), 113-122.

Topan, A., Lupse, M., Calin, M., Jianu, C., Leucuta, D.-C., & Briciu, V. (2023). 25 Hydroxyvitamin D Serum Concentration and COVID-19 Severity and Outcome—A Retrospective Survey in a Romanian Hospital. Nutrients, 15(5), Article 5. https://doi.org/10.3390/nu15051227

Vaughan, M., Trott, M., Sapkota, R., Premi, G., Roberts, J., Ubhi, J., Smith, L., & Pardhan, S. (2022). Changes in 25-hydroxyvitamin D levels post-vitamin D supplementation in people of Black and Asian ethnicities and its implications during COVID-19 pandemic: A systematic review. Journal of Human Nutrition and Dietetics: The Official Journal of the British Dietetic Association, 35(5), 995-1005. https://doi.org/10.1111/jhn.12949

Wang, L., Wang, Y., Ye, D., & Liu, Q. (2020). Review of the 2019 novel coronavirus (SARS-CoV-2) based on current evidence. International Journal of Antimicrobial Agents, 55(6), 105948. https://doi.org/10.1016/j.ijantimicag.2020.105948

Xu, Y., Baylink, D. J., Chen, C.-S., Reeves, M. E., Xiao, J., Lacy, C., Lau, E., & Cao, H. (2020). The importance of vitamin d metabolism as a potential prophylactic, immunoregulatory and neuroprotective treatment for COVID-19. Journal of Translational Medicine, 18, 322. https://doi.org/10.1186/s12967-020-02488-5

Yoon, J., Park, B., Kim, H., Choi, S., & Jung, D. (2023). Korean Red Ginseng Potentially Improves Maintaining Antibodies after COVID-19 Vaccination: A 24-Week Longitudinal Study. Nutrients, 15(7), Article 7. https://doi.org/10.3390/nu15071584

Zaazouee, M. S., Eleisawy, M., Abdalalaziz, A. M., Elhady, M. M., Ali, O. A., Abdelbari, T. M., Hasan, S. M., Almadhoon, H. W., Ahmed, A. Y., Fassad, A. S., Elgendy, R., Abdel-Baset, E. A., Elsayed, H. A., Elsnhory, A. B., Abdraboh, A. B., Faragalla, H. M., Elshanbary, A. A., Kensara, O. A., & Abdel-Daim, M. M. (2023). Hospital and laboratory outcomes of patients with COVID-19 who received vitamin D supplementation: A systematic review and meta-analysis of randomized controlled trials. Naunyn-Schmiedeberg’s Archives of Pharmacology, 396(4), 607-620. https://doi.org/10.1007/s00210-022-02360-x




DOI: https://doi.org/10.23857/pc.v9i2.6841

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