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Comportamiento Termotrópico de los lípidos, revisión bibliográfica
Resumen
Los estudios biofísicos sobre el comportamiento termotrópico de los lípidos ha permitido conocer el mecanismo molecular de los lípidos que conforman la bicapa lipídica de las células procariotas y eucariotas al someterlas a ciertas temperaturas. Sin embargo, estos organismos presentan un alto grado de complejidad por ello los datos obtenidos son el resultado de estudios a base de membranas modelo o sintéticas como micelas y liposomas que fueron extrapolados a membranas naturales. Las transiciones de fase están estrechamente ligadas al tipo de lípido porque la temperatura de transición es propia de cada lípido, grado de saturación y largo de cadena de las colas de ácidos grasos, también depende de la concentración de componentes secundarios como esteroles que afectan la temperatura de transición, aboliendo la fase de pretransición y a concentraciones mayores la transición principal. Finalmente, el comportamiento termotrópico en el ámbito farmacéutico ha contribuido en el control de calidad de biofármacos evitando que estos presenten inestabilidad.
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Referencias
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DOI: https://doi.org/10.23857/pc.v7i2.3623
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